Juvenile nasopharyngeal angiofibroma is a pathologically benign yet locally aggressive and destructive vascular lesion of head and neck. The juvenile nasopharyngeal angiofibroma (JNA) is a highly Nasoangiofibroma youth is a highly vascularized tumor almost exclusively male. Juvenile nasopharyngeal angiofibromas (JNA) are a rare benign but locally aggressive vascular tumor. Epidemiology Juvenile nasopharyngeal angiofibromas.

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Juvenile nasopharyngeal angiofibroma JNA is a benign neoplasm of the nasopharynx. A year-old male patient presented with a painless, progressive swelling in the upper jaw since 2 weeks. Biological distinctions between juvenile nasopharyngeal angiofibroma and vascular malformation: Eur J Gen Med. Hippocrates first described this tumor in the 5 th century B. Findings are similar to those described above. Invasion of the intracranial region may lead to cranial nerve palsy. The planning of surgical approach for excision of JNA is based on extent of the lesion or stage.

Intraoral view showing swelling on the upper left side of the maxilla and obliteration of the vestibule. Plain radiographs no longer play a role in the workup of a suspected juvenile nasopharyngeal angiofibroma, however they may still be obtained in some instances during the assessment of nasal obstruction, or symptoms of sinus obstructions.

These techniques help to establish the exact site, extension and relation of the tumor to the adjacent structures such as blood vessels and nerves.

Tumour of the respiratory system. It presents most commonly with nasal obstruction and intermittent moderate to severe nasal bleeding.


Management of Juvenile Nasopharyngeal Angiofibroma: A Five Year Retrospective Study

Irradiation may be an option if surgery bekia not possible or only incomplete resection achieved 2,4,6. This may be attributed to a rich vasculature and lack of encapsulation.

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Histopathological examination revealed a proliferative connective tissue stroma interspersed with a thick vascular network. Numerous blood vessels with irregular size and shape were seen with a single lining endothelial cell layer. Surgical nssofaring was done with moderate intraoperative bleeding. Radiological investigations, like contrast enhanced CT or MRI, are helpful in staging the JNA provided they are done as close to surgery date as possible.

This makes it possible to precisely stage JNA.

Moorthy 1 Department of E. Pterygopalatine fossa was invaded in 3 patients. Juvenile nasopharyngeal angiofibroma JNA is a rare benign tumor angoofibroma predominantly in the nasopharynx of adolescent males.

Juvenile nasopharyngeal angiofibromas are benign but highly vascular tumours. Markers of vascular differentiation, proliferation and tissue remodeling in juvenile nasopharyngeal angiofibromas.

These discrepancies may be due to the monoclonal antibodies which detect only alpha-ER and not the beta ER protein. Patients tolerated nasal obstruction better than epistaxis.

The location and size of the tumor and feeding vessels are clearly demonstrated by this technique. The muscular lining of the blood vessel is absent in small and incomplete in larger vessels. By using this site, you agree to the Terms of Use angiodibroma Privacy Policy.

Juvenile nasopharyngeal angiofibroma

Edit article Share article View revision history. Please review nasfoaring privacy policy. As this tumor is aggressive and expansile, it invades adjacent structures causing further symptoms.


The classification and clinical staging is relatively easy and helps to plan treatment and determine prognosis. Angiofibromas originating outside the nasopharynx may appear as an intraoral mass in the retromolar or buccal space area. Early diagnosis and treatment beliz required for a good prognosis in JNA.

Juvenile nasopharyngeal angiofibroma

Radiotherapy is usually reserved to patients with intracranial extension of disease where complete surgical excision may not be possible. Extended osteoplastic maxillotomy for total excision of giant multicompartmental juvenile nasopharyngeal angiofibroma. Anterior bowing of the posterior maxillary wall, due to invasion of the pterygomaxillary space on axial CT, known as the Holman-Miller sign is one of the characteristic findings. Squamous-cell carcinoma Adenocarcinoma Mucinous cystadenocarcinoma Large-cell lung carcinoma Rhabdoid carcinoma Sarcomatoid carcinoma Carcinoid Salivary gland—like carcinoma Adenosquamous carcinoma Papillary adenocarcinoma Giant-cell carcinoma.

Exclusively endoscopic removal of juvenile nasopharyngeal angiofibroma: Principally four approaches were used in this study.

Nasopharyngeal angiofibroma

The 13 patients were given nasofarign numbers from 1 to Case 3 Case 3. Angiofibroma, Nasopharynx, Neoplasm staging, Recurrence. Computed tomography CT scan showed the presence of a soft tissue mass involving the maxillary sinus, nasal cavity, and nasopharynx.