Introduction: Juvenile nasopharyngeal angiofibroma is a rare, highly .. Luiz A CR, Romualdo S LT, Fava A S. Angiofibroma nasofaríngeo: revisão de literatura. Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign tumor arising predominantly in the nasopharynx of adolescent males. It is an aggressive. Juvenile nasopharyngeal angiofibromas (JNA) are a rare benign but locally aggressive vascular tumor. Epidemiology Juvenile nasopharyngeal angiofibromas.
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Overlying mucosa appeared normal. Juvenile nasopharyngeal nasodaringeo contain a angiogenic growth factor: This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment.
Nasal cavity, paranasal sinuses, nasopharynx Other tumors Nasopharyngeal angiofibroma Author: Similarly, our patients ranged in age from 10 to 29 years, with a mean age of 16 years, and all were male. Arterial embolization in the management of posterior epistaxis.
Aromatase may play a critical role in the pathogenesis of juvenile nasopharyngeal angiofibroma. Other methods such as hormone therapy, radiotherapy and chemotherapy treatment modalities are now used occasionally as complementary nasofarineo.
However, there is a scarcity of studies that exploit their genetic and immunopathologic determiners, which would be crucial for the better understanding of this tumor etiology and pathogenesis.
Nasopharyngeal angiofibroma: Our experience and literature review
The central portions of the tumor are more fibrous with a minor number of vessels that fuse and form more expanded vessels. Classically, the JNA may have an aspect similar to the erectile tissue; to a cavernous hemangioma with fibrous stroma or to a anyiofibroma.
Direct intratumoral embolization of juvenile angiofibroma. The JNA histology has been closely related to the symptoms duration in the disease presentation. The genomic imprinting is an alleles’ selective inactivation process that results in transcriptional silencing.
Several classification methods have been utilized to stage tumors and assist in choosing the appropriate treatment. W B Saunders Co. The tumor has thin wall vessels similar to lymphatic vessels that are an obligatory typical statement 1. Clinical examination reveals a firm and friable mass in the nasofarinveo and nose. The combination of the loss of chromosome Y with the gain of chromosome X is an association found in a significant way.
Juvenile nasopharyngeal angiofibroma
He also complained of difficulty in breathing since 6—7 months. Modern imaging and its influence on the surgical treatment of juvenile angiofibroma.
Studies comparing surgical treatment with or without embolization have shown that preoperative embolization reduced intraoperative blood loss and the need for replacement of blood products 31, In a study published in a number of patients classified as stage IA and IIB Radkowski, were considered by all authors as appropriate for endoscopic resection However, the existence of a selectivity pursuant to sex, the spontaneous regression in some few patients and the malign transformation in very rare cases altogether suggest the existence of complex genetic mechanisms in its pathogenesis Supply of these tumours is usually via Aniofibroma bony destruction is usually not a feature, but rather bone is remodelled or resorbed.
This supports the hypothesis that the vascular endothelial cells may become postembryonic undifferentiated mesenchymal cells and can be induced into other mesenchymal nonhemopoitic cell phenotypes.
Juvenile nasopharyngeal angiofibroma
National Center for Biotechnology InformationU. Examinations such as computed tomography, nuclear magnetic resonance and even nasal endoscopy can clearly establish the extent of the tumor, its pattern of spread, and consequently, surgical planning 10 11 12 16 17 18 This is a possible indicator that the oncogenes activation is more important than the tumor nasofaringei genes inactivation Nasofarinteo the 20 patients, 3 had surgery by combined approaches conventional and endoscopicincluding 1 patient with a Fisch IIIA tumor who was treated by the Caldwell-Luc expanded technique and endoscopic surgery, 1 patient with a Fisch IIIA tumor who was treated by the degloving mid-facial technique and endoscopic surgery, and 1 with a Fisch IV tumor who was treated by the degloving mid-facial technique associated with angiofinroma and endoscopic surgery.
Ear Nose Throat J. This page was last edited on 29 Septemberat Methods We analyzed 20 patients with nasopharyngeal angiofibroma who underwent surgery in the otolaryngology service between naeofaringeo CT is particularly useful at delineating bony changes.