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AVONEX PACKAGE INSERT PDF

1. Package leaflet: Information for the user. AVONEX 30 micrograms/ ml solution for Injection. (Interferon beta-1a). Pre-filled syringe. Read all of this leaflet. Package leaflet: Information for the user. AVONEX 30 micrograms/ml solution for injection in pre-filled pen. (Interferon beta-1a). Pre-filled pen. Read all of this. Formal hepatic drug metabolism studies with AVONEX PS/AVONEX PEN in This leaflet is part III of a three-part “Product Monograph”.

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Attach the needle by pressing it onto the syringe and turning it clockwise until it locks in place. If your doctor tells you to stop using AVONEX or the expiry date has passed, ask your pharmacist what to do with any medicine that is left over.

Your pacoage can discuss with you the possible risks involved. The medicine should be clear and colourless or slightly yellow. The most common side effect is to feel ‘flu-like’ symptoms, e. Monitoring of liver function tests is recommended at regular intervals 1, avones, and 6 months recommended for Rebif following initiation of therapy and then periodically thereafter in the absence of clinical symptoms.

The pre-filled syringe cap of interferon beta-1a contains natural rubber latexwhich may cause hypersensitivity reactions in those patients with latex hypersensitivity. Serious side effects are rare. Beta2-microglobulin, neopterin, and tryptophan, and inhibition of concanavalin-stimulated proliferation of peripheral blood mononuclear cells. The above list includes the more common side effects of AVONEX, or these effects might be related to your avoex health or the MS process, or to a combination of these.

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Major An increased risk and severity of peripheral neuropathy has been reported with telbivudine alone or in combination with pegylated interferon alfa-2a and other pacmage. Biologic response marker levels usually peak within 48 hours of dosing.

Cases of thrombotic microangiopathy, including thrombotic thrombocytopenic purpura TTP and hemolytic-uremic syndrome HUShave been reported with interferon beta-1a. Visually inspect parenteral products for particulate matter and discoloration prior to administration whenever solution and container permit.

Many studies demonstrate that nevirapine is more hepatotoxic than efavirenz. Emtricitabine; Tenofovir disoproxil fumarate: If the goal dose is 22 mcg, in weeks 1 to 2 administer 4. Closely monitor patients for treatment-associated toxicities, especially hepatic decompensation. Data from a large, multicenter trial of pregnant patients with Oackage suggest that patients have a decrease in the number and severity of MS relapses during pregnancy, despite discontinuation or lack of receipt of disease-modifying medications.

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If you are not sure whether you should use this medicine, talk to your doctor or pharmacist. Send the page ” ” to a friend, relative, colleague or yourself. MS affects the brain and spinal cord. It is not known whether these events were related to the effects of multiple sclerosis alone, interferon beta-1a therapy, or a combination of both. Specific guidelines for dosage adjustments in hepatic impairment are not available; insrt appears that no dosage adjustments are needed.

Patients with bone marrow suppression may require more intensive monitoring of hematologic parameters, including complete blood counts with differential and platelets.

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Major Patients receiving stavudine with interferons with or without ribavirin should be closely monitored for treatment-associated toxicities, especially hepatic decompensation. We do not record any personal information entered above.

It is important that a qualified health care professional supervises your first injection.

Avonex (interferon beta-1a) dose, indications, adverse effects, interactions from

Interferon beta is a Type I interferon. Hepatic injury including elevated hepatic enzymes, jaundice, and hepatitis, some of which have been severe, has been reported in patients receiving interferon beta-1a see Adverse Reactions.

The syringe needle should point toward the inserg end of the device, and inseert plunger should point toward the thick end of the device that has a “collar”. Cases have been reported several weeks to years after treatment initiation. Concomitant use of ocrelizumab with interferon beta may increase the risk of immunosuppression. Interferon beta-1a should be used with caution in patients with depression.

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Used to treat epilepsy prevent fits. However, a small number of nursing mothers receiving interferon beta-1a reported no adverse effects in their partially breast-fed infants, and the amount of interferon beta-1a excreted into breast milk appeared to be insignificant.

Nevirapine may cause liver damage packaage the context of hypersensitivity reactions or by direct toxic effects.