Dornase alfa cleaves extracellular DNA to 5´-phosphodinucleotide and Deoxyribonuclease (human clone protein moiety); Dornasa alfa. Date of last search for all years available: 20 May Using the option ‘ Advanced search’, the following search terms were entered into the following fields. El impacto de primer año de tratamiento con dornasa alfa en los parámetros clínicos de pacientes con fibrosis quística: resultado de estudio brasileño.

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It is known that an important aspect of CF evolution and prognosis is the rate of lung function decline, and slowing this rate is crucial for long-term survival If you become pregnant while using dornase alfa, call your doctor.

For each patient, dornasx three forms and the following parameters were collected: The Pulmozyme Study Group. Gastrointestinal and reproductive systems are also affected with pancreatic insufficiency with maldigestion and malabsorption of nutrients, distal intestinal obstruction, and hepatic disease.

Clarke SA, Eiser C. This is an Open Access article distributed under the terms of the Creative Commons Attribution Dornaa License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

In all age groups, P. Articles needing additional references from December All articles needing additional references Template: This study received technical support and medical advises from Dr. Dornaa is this medication prescribed? The colonization was defined as chronic when 3 positive samples were obtained, in previous 6 months. The results were also witnessed in patients.


Dornase alfa – Wikipedia

To review the literature evaluating the efficacy of dornase alfa for non-cystic fibrosis pediatric patients with pulmonary atelectasis. B No risk in non-human studies. Dornase alfa was overall well tolerated, with only a few patients experiencing worsening atelectasis posttreatment. Dornase alfa comes as a solution doenasa inhale by mouth.

Dornase odrnasa hydrolyzes the DNA in sputum of CF patients and reduces sputum viscosity and viscoelasticity. Drug created on June 13, Monaldi Arch Chest Dis.

Linguistic validation of cystic fibrosis quality of life questionnaires. Dornase alfa is the most recent therapeutic agent zlfa with this basic mechanism of action.


Dornase alfa is an orphan drug. The safety of dornase alfa has not been studied in pregnant women, nursing women and children under the age of 5 years old. Recently, an association between the use of dornase alfa for a period of two years and the reduction in the rate of FEV 1 decline was observed in a large prospective observational study In this respect, we may speculate that our colonization results are not consistent with dornnasa clinical outcomes observed: It is important to keep all medication out of sight and reach of children as many containers such as weekly pill minders and those for eye drops, creams, patches, and inhalers are not child-resistant and young children can open them easily.


Our aim was to investigate whether the improvements observed in patients’ QoL 14 would also reflect benefits in clinical status. The amino acid sequence of dornase alfa is identical to the endogenous human enzyme. Studies in rats indicate that, vornasa aerosol administration, the disappearance half-life of dornase alfa from the lungs is 11 hours. Pulmonary function parameters and data related to hospitalization are presented in Tables 1 to 3.

O escore de Shwachman-Kulczychi melhorou significativamente no grupo de mais idade. Your doctor may order certain lab tests to check your response to dornase alfa.


Due to sample size limitations, no statistical comparisons were made for this group regarding outcomes over time. Effect of aerosolized rhDNase Pulmozyme on pulmonary colonization in patients with cystic fibrosis.

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