;(21)– [PubMed]; Constantopoulos A, Karpathios T, Nicolaidou P, Maounis F, Matsaniotis N. Lazy-leukocyte syndrome. A case report . The lazy leukocyte syndrome was first described by Miller et al. in in two children with recurrent infection. They had normal humoral and cellular immunity . – LAZY LEUKOCYTE SYNDROME. LAZY LEUKOCYTE SYNDROME. Clinical Synopsis Toggle Dropdown. Inheritance. -? Autosomal dominant new.

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The year-old proposita had neutropenia and an illness suggestive of zyndrome Epstein-Barr virus infection. Expert curators review the literature and organize it to facilitate your work.

lazy leukocyte syndrome

While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions. The syndrome is distinguished from neutrophil chemotactic deficiencies by the coexistence of defective random motility and peripheral sybdrome neutropenia with normal bone marrow granulocyte reserve.


A new disorder of neutrophil function.

Pathology of chemotaxis and random mobility. Autosomal dominant new mutations.

Lazy leukocyte syndrome.

None is familial and no parental consanguinity is known. Mobilization of leukocytes after exercise was defective.

Both random mobility and chemotactic function were defective. Looking For More References? Transient ‘lazy-leukocyte’ syndrome during infancy. Bone marrow studies showed normal numbers of mature, morphologically normal neutrophils. A characteristic abnormality of actin distribution in neutrophils was demonstrated.

Unfortunately, it is not free to produce. Clinical Synopsis Toggle Dropdown. A bonus to all MIMmatch users is the leujocyte to sign up for updates on new gene-phenotype relationships.

Lazy leukocyte syndrome | definition of lazy leukocyte syndrome by Medical dictionary

Single cases were reported by Costanopoulos et al. Miller knew of 4 other cases.

A severe neutropenia was found. Syndroe is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. We need long-term secure funding to provide you the information that you need at your fingertips. Please consider making a donation now and again in the future.


Relative to the genetics and the possibility that these cases represent new dominant mutations, parental age data would be of interest. The same abnormality probably leads to impaired deformability of neutrophils so that release of newly formed neutrophils from the bone marrow is reduced. Skin window mobilization test and chemotaxis were normal.

Leukocyte phagocytosis and bactericidal activity were normal. A poor neutrophil response was obtained upon stimulation with both epinephrine and endotoxin, as well as upon induced inflammation by the Rebuck skin window technique. We are determined to keep this website freely accessible.